Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Abstract Background A cumulative environmental exposure score for schizophrenia (exposome [ES-SCZ]) may provide potential utility risk stratification and outcome prediction. Here, we investigated whether ES-SCZ was associated with functioning in patients spectrum disorder, unaffected siblings, healthy controls. Methods This cross-sectional sample consisted of 1,261 patients, 1,282 1,525 The Global Assessment Functioning (GAF) scale used to assess functioning. calculated based on our previously validated method. association between the GAF dimensions (symptom disability) analyzed by applying regression models each group (patients, controls). Additional included polygenic (PRS-SCZ) as a covariate. Results (symptom: B = −1.53, p -value 0.001; disability: −1.44, 0.001), siblings −3.07, < −2.52, controls −1.50, −1.31, 0.001). results remained same after adjusting PRS-SCZ. degree associations both symptom disability were higher than By analyzing an independent dataset (the Genetic Risk Outcome Psychosis study), replicated observed patient group. Conclusions Our findings suggest that shows promise enhancing prediction research practice. From clinical perspective, aid efforts characterization, operationalizing transdiagnostic staging models, personalizing management.